Preprint Highlight: Constriction forces imposed by basement membranes regulate developmental cell migration
Highlighted By: Daniel Rios, Universidad Nacional Autonoma de Mexico
Preprint DOI: https://doi.org/10.1101/2022.12.19.520983
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Significance Statement:
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Extracellular matrix (ECM) stiffness affects many processes of ECM-associated cells, such as migration and differentiation. Whether ECM mechanical properties also affect distant cell populations remains largely unexplored. This preprint studies migration of border cells within Drosophila ovarian follicles as a model system. Border cells migrate toward the center of the follicle by moving between nurse cells, which are surrounded by follicle cells that are themselves encased by the basement membrane ECM.
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Decreasing stiffness of the follicle ECM reduced cortical tension of follicle cells, and of nurse cells indirectly, accelerating border cell migration. Increasing follicle cell cortical tension slowed border cell migration.
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These results may inform how ECM stiffness affects cell migration within other complex tubular tissues, such as blood vessels.
Read the Preprint:
Constriction forces imposed by basement membranes regulate developmental cell migration
Ester Molina López, Anna Kabanova, Maria D. Martín-Bermudo
bioRxiv 2022.12.19.520983; doi: https://doi.org/10.1101/2022.12.19.520983
This Preprint Highlight was previously published in Molecular Biology of the Cell on Mar 31, 2023: https://doi.org/10.1091/mbc.P23-02-0008
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